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In diabetic hypertrophy, lipotoxicity, insulin resistance, mitochondrial calcium overload, oxidative stress, and ferroptosis may dominate (2022, 37, 72)
In addition, rebalancing of substrate utilization at both organ and whole body level by FGF21 should contribute to improving and maintaining whole body metabolic homeostasis
The study was limited to people of European origin and may not apply to other populations, which may explain the reason why we did not find a causal association between SOD1 and ALS
Under conditions of oxidant attack, GSH is rapidly converted to GSSG, making the elevation of the intracellular GSSG/GSH ratio a widely accepted marker for oxidative stress
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