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Supplementary information, including Supplementary Figs
The retatrutide comparison is compelling but based on earlier-stage research
While dietary interventions emphasizing protein, fiber, and whole foods can improve metabolic parameters and support weight management, the effects are generally more modesttypically 3-5% weight loss and HbA1c reductions of 0.5-1.0% when implemented without other interventions, as seen in programs like the Diabetes Prevention Program
Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono, K and Ichijo H
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