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Technical and Peer-Reviewed Citations Coskun T, et al

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3.3 Proposed Mechanism for the Difference in the Semaglutide Pharmacokinetic Profile Observed Between IcoSema and Semaglutide Administration The change in the semaglutide pharmacokinetic profile when semaglutide is combined with icodec in IcoSema gave rise to the hypothesis that there could be an interaction between icodec and semaglutide locally at the injection site in the subcutaneous tissue, since both molecules bind to albumin