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NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation

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(3) Inhibiting Adipose Tissue Inflammation and Improving the Adipose Microenvironment In obesity, adipose tissue develops chronic lowgrade inflammation with abundant release of proinflammatory factors (such as TNF and IL6), disrupting the adipose microenvironment, further worsening fat metabolic abnormalities and insulin resistance, and forming a vicious cycle

[Additional acetaminophen metabolism and toxicity references available in full bibliography] 73