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Research indicates that fasting may stimulate cellular pathways that enhance the synthesis of glutathione, ultimately supporting antioxidant defenses

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Therefore, while efforts undoubtedly need to be intensified towards preventing the onset of the disease and making lifestyle modifications (a fundamental aspect of the therapy for every patient with T2DM), it is clear, as indicated by the most recent guidelines [78], that the pharmacological approach should focus on timely treatment that leaves no room for therapeutic inertia and employs medications that are as effective as possible in both metabolic control and the prevention of chronic complications

"Behavior is always important but you have to let the pharmacology work." While there is no standard protocol to follow, Ashton said a doctor may try to get a patient to their target, healthy goal weight and then follow the "basic principle of pharmacology" in decreasing the patient to the lowest dose of the medication possible