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Facilities must meet cGMP and FDA/EMA standards, with HEPA filtration, stainless steel surfaces, and validated HVAC systems
Common oxidant sources include cigarette smoke, pesticides and herbicides (e.g., organophosphates), industrial chemicals (e.g., organochlorines), excessive alcohol, air pollution and diesel/gasoline soot, inhalable quartz and metal powders, and certain mineral fibers
Whether this pattern persists beyond 52 weeks, whether it is dose-dependent, and whether it is reversible upon discontinuation of therapy are questions that remain unanswered and need to be addressed in larger, longer-duration trials
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