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Produced by the liver in response to GH, it activates the IGF-1R receptor in muscle cells, triggering the PI3K/Akt/mTOR pathway, which stimulates protein synthesis, inhibits proteolysis, and promotes the proliferation of satellite cells (muscle precursors)

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By precisely modulating the activation state of trained immunity, it may be possible to suppress pathological inflammation while preserving essential immune defenses, offering promising new avenues for the treatment of inflammation-related diseases and chronic complications