In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization
A diet rich in animal products, fortified foods, nutritional yeast, and supplements helps maintain adequate B12 levels
You cant take too much B12
Insider's takeaway The Institute of Medicine has not established a tolerable upper intake level of B12 because studies show no adverse health effects when taking excess levels of B12, either through food or supplements