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Ligand binding drives receptor autophosphorylation, IRS-1/IRS-2 adapter recruitment, and activation of two primary downstream cascades: PI3K/Akt/mTOR (governing protein synthesis, glucose uptake, and cell survival) and MAPK/ERK (regulating cell proliferation and differentiation)
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Vicente, R., Noel, D., Pers, Y
As exercise begins, cardiac output increases along with blood flow through the vasculature of the working skeletal muscle
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