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Tirzepatide is structurally based on the native GIP peptide sequence with modifications that confer dual GIP and GLP-1 receptor agonism from a single molecule, along with a fatty acid conjugation that extends the half-life to approximately five days and promotes albumin binding for sustained blood levels between weekly injections
Lancet Diabetes Endocrinol 7(10):776785 Kosiborod MN, Abildstrm SZ, Borlaug BA, Butler J, Rasmussen S, Davies M, Hovingh GK, Kitzman DW, Lindegaard ML, Mller DV et al (2023) Semaglutide in patients with heart failure with preserved ejection fraction and obesity
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Molecular weight340.38 g/mol CHCuNO
