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(PDF) Harnett, N.G., van Rooij, S.J.H., Ely, T.D., Lebois, L.A.M., Murty, V.P., Jovanovic, T., Hill, S.B., Dumornay, N.M., Merker, J.B., Bruce, S.E., House, S.L., Beaudoin, F.L., An, X., Zeng, D., Neylan, T.C., Clifford, G.D., Linnstaedt, S.D., Germine, L.T., Bollen, K.A., Rauch, S.L., Lewandowski, C., Hendry, P.L., Sheikh, S., Storrow, A.B., Musey, P.I., Jr.19, Haran, J.P., Jones, C.W., Punches, B.E., Swor, R.A., McGrath, M.E., Pascual, J.L., Seamon, M.J., Mohiuddin, K., Chang, A.M., Pearson, C., Peak, D.A., Domeier, R.M., Rathlev, N.K., Sanchez, L.D., Pietrzak, R.H., Joormann, J., Barch, D.M., Pizzagalli, D.A., Sheridan, J.F., Harte, S.E., Elliot, J.M., Kessler, R.C., Koenen, K.C., Mclean, S., Ressler, K.J., Stevens, J.S

A 2025 systematic review and meta-analysis in Reviews in Endocrine and Metabolic Disorders found that tirzepatide (the active ingredient in Mounjaro and Zepbound) reduced hsCRP by approximately 33% and IL-6 by approximately 18% compared to placebo across patients with and without diabetes. A growing body of research suggests this effect occurs through direct action on the NF-B pathway, a master switch of inflammation

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However, only lowest SpO 2 outcome in the population with T2DM crossed the traditional boundary and TSA threshold but did not reach RIS, indicating the possibility of a false negative result