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Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis *

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TNF-, IL-1, IL-6, and IL-12 are a few proinflammatory cytokines that are produced and secreted in relation to M1 microglia polarization, which in general react to defend tissue and increase the elimination of infections