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Although extracellular vesicles, oxidized phospholipids, secreted proteins, and lipid-derived electrophilic metabolites all represent plausible candidates, it remains unclear which mediators possess sufficient stability and diffusivity to support propagation across anatomically separated yet functionally connected cells

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Key questions should address any personal history of thyroid nodules, thyroid cancer, or thyroid surgery, as well as detailed family history of MTC, MEN 2, or other endocrine tumors across multiple generations