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PMID 11118286
Further mechanistic studies showed that NNMTi increases intracellular NAD levels and activates the SIRT1 pathway by inhibiting NNMT, thereby suppressing the transcription of adipogenic genes and preventing the maturation of preadipocytes.This research provides a new perspective for understanding the molecular mechanism of adipocyte differentiation, confirms the key role of NNMTi in regulating adipogenesis, and lays a foundation for subsequent obesity intervention studies
Higher spermidine intake is linked to lower mortality: a prospective population-based study
Peptides that more directly influence testosterone include hCG, which stimulates testicular production, and kisspeptin-10, which activates the hypothalamic signaling that drives testosterone release
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