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In line with these data, the GLP-1R has been found to be co-expressed in ARC POMC neurons in both rats (Sandoval et al., 2008) and mice (Ronnekleiv et al., 2014) suggesting that GLP-1 can act directly on these neurons

Dosing tirzepatide within 23 hours of sermorelin doesn't negate its efficacy outright, but it does introduce variability in absorption rate that some patients report as inconsistent appetite suppression or delayed onset of nausea during titration

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