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Detailed methods are provided in Supplementary Information

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Thus, it is reasonable to use GLP-1based therapy as add-on therapy to SGLT2i in individuals with T2D, HFpEF, and additional CKM risk factors or related conditions, such as obesity (Section 6.3.1, CKM Syndrome Stage 4 With Obesity and HF), CKD with albuminuria (Section 6.3.3, CKM Syndrome Stage 4 With CKD and HF), MASLD (Section 7.2, Metabolic DysfunctionAssociated Steatotic Liver Disease), and ASCVD (Section 6.2.2, CKM Syndrome Stage 4 With T2D and ASCVD)

Despite its prevalence and impact, there have been no new FDA-approved treatments for PTSD in over 20 years