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Other preclinical investigations demonstrated positive benefits of SF on AD by attenuating A oligomers-mediated reduction of phagocytic activity (5 M for 24 h) (72), reducing streptozotocin-induced cognitive deficits (141 or 282 mol/kg/day for 6 weeks) (73), decreasing neuroinflammation and inhibiting tau phosphorylation (1 or 2 M for 1 h and stimulated with LPS for 23 h) (73), and reducing A production (226 mol/kg three times a week for 4 weeks) (74) in in vivo and in vitro AD models
GSSG is reduced back to GSH by the enzyme glutathione reductase, which also requires NADPH as a cofactor
WBCILs liposomes mimic natural cell membranes, allowing glutathione to fuse directly with cells or enter through endocytosis
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