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Brain insulin resistance is heavily implicated in the pathogenesis of Alzheimers disease, and takes part in amyloid-- and tau phosphorylation-mediated neuronal damage (Mullins et al., 2017)

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A better understanding of how these genes are regulated by -adrenergic and MEF2 pathways could provide insights into the mechanisms of heart failure and potential therapeutic targets (Tobin et al., 2017