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Peer review Peer review information Nature Communications thanks Chengyong Tang and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

As a specific example: do these multi-agonists act simultaneously at multiple receptors residing at a single tissue or even a single cell

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By activating GLP-1 receptors, natural GLP-1 and GLP-1RAs reduce insulin resistance, suppress neuroinflammation and oxidative stress, and prevent negative changes in neuroplasticity