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[21] Neurological symptoms: Sensory or motor deficiencies (absent reflexes, diminished vibration or soft touch sensation), subacute combined degeneration of spinal cord, or seizures
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Recently, a new DON prodrug, DRP-104 (sirpiglenastat) was developed, which carries isopropyl ester and acetylated tryptophan on the C-terminal and N-terminal of DON (Rais et al., 2022)
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