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18 In these patients, pre-existing risk factors for biliary disease, such as insulin resistance (IR), dyslipidemia, and metabolic alterations, predispose them to abnormal bile composition and an increased risk of gallstone formation

First, assess the situation: Determine exactly how much extra medication you have taken Note the time of administration Check whether you have taken your other diabetes medications as usual If possible, measure your blood glucose level Contact healthcare services immediately for guidance

The increased risk of amputation seen in the large, long-term Canagliflozin Cardiovascular Assessment Study (CANVAS) trial for canagliflozin, and select observational studies, merits further research but overall, there is currently no consistent evidence of SGLT2i exposure and increased risk of amputation

Abstract presented at: Heart Rhythm 2025