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Franz et al
A decrease in IGF-I levels in AD and VD has been widely documented and it may be involved in the development of neurofibrillary tangles, abnormal amyloid metabolism and aberrant Tau phosphorylation, cognitive loss, neural inflammation, oxidative stress or mitochondrial dysfunction, among others[68, 325]
So, basically, anything that can avoid that is major
The linearity of the modified GPx-DTNB assay was assessed by comparing its results to those of the original GPx assay method (Rotruck et al
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