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Pro-inflammatory cytokines, including IL-6, IL-1, and TNF-, promote M1-type TAM formation, inhibit iron release into the tumor immune microenvironment (TIME), and exert anti-tumor effects ( + ) bind to FT for transport throughout the body

First identified in human plasma by Dr

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A 50% dose reduction (0.5-1 mg subcutaneously, 3 times per week maximum) is a reasonable starting point