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We have therefore necessarily made a number of assumptions about the loss of GSH, GSSG, Cys, Gly, and Glu to other tissues

Considering this, the elevated concentrations of these metabolites (sedoheptulose, mannoheptulose and 1.3-diaminopropane) are likely due to reduced growth and nucleotide synthesis due to nutrient deprivation, and a redirection of this pathway towards energy generation and preventing oxidative stress

These factors include: Aging : Glutathione production gradually declines with age, making it harder for the body to manage oxidative stress and maintain optimal cellular health

Glutathione is your bodys master antioxidant, but only if it gets absorbed