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Its molecular target is nicotinamide N-methyltransferase (NNMT), a cytosolic S-adenosyl-L-methionine-dependent methyltransferase that converts nicotinamide to 1-methylnicotinamide, consuming SAM and releasing S-adenosylhomocysteine
The patients used six different doses 0 mg (placebo), 1mg, 5 mg, 10 mg, 20 mg and 30 mg
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