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The researchers suggest it may be a GLP-1 effect, since curcumin stimulates GLP-1 in rodents, as well as in cells in a petri dish, but there hasnt been a human studyuntil now
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Similarly, the study could not find any association between changes in circulating GLP-1 and changes in IBS symptom severity, highlighting the need for identifying underlying mechanisms driving these changes
The Semaglutide cohort compared with the Non-GLP-1RA anti-obesity medications cohort was older and had a higher prevalence of morbid obesity, T2D and obesity-associated comorbidities, and a lower prevalence of mental disorders and substance use disorders
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