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Therefore, GLP-1RA drugs like liraglutide or semaglutide can counteract DPP-4 degradation, prolonging the GLP-1R signal and maintaining insulin secretion via the mTOR-dependent HIF-1 pathway (34)

Lipase inhibitors such as alli or Xenical (orlistat) have been associated with rare liver injury and patients should be alert for signs of liver disease such as itching, yellow skin or eyes (jaundice), stomach pain, loss of appetite, pale or tar-colored stools, brown-colored urine (due to excess bilirubin in the urine)

Also, pretreatment with MAPK & c-jun N-terminal kinase inhibitors exhibited an inhibitory effect on death, suggesting that the MAPK pathway was the medium via which the SBGEs apoptotic effects passed (93)