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As a result, the half-life of GLP-1 RAs, which would otherwise be as short as 2 minutes, is extended to approximately 10 to 18 hours, enabling liraglutide to maintain adequate blood levels even when administered once a day

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Nat Rev Endocrinol 2013;9:1327

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While the exact cause is not fully understood, it is believed to be related to how semaglutide affects digestion and intestinal motility

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It is the first and only GIP and GLP-1 receptor agonist medication that activates natural incretin hormones to regulate blood sugar levels

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