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This selectivity is why it became the preferred pairing with CJC-1295

The streptavidin-HRP conjugate and TMB substrate amplify the signal, enabling detection of GSH-PX concentrations as low as 0.1 U/mLsufficient to quantify subtle changes in oxidative stress (e.g., early-stage drug-induced hepatotoxicity in rats)

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One of the most promising strategies to overcome this multi-drug resistance, MRP1-mediated CS, relies on the ability of certain ligands of MRP1 to induce a massive MRP1-dependent GSH efflux, that depletes the cells of their anti-oxidant defense, leading to their selective cell death 15