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This makes injections highly effective for pernicious anaemia and other malabsorption syndromes, including post-gastrectomy states, Crohn's disease affecting the terminal ileum, and certain medications that interfere with B12 uptake

It is currently researched for among the following applications [14, 18]: Cell migration and tissue repair Formation of new blood vessels Maturation of stem cells Survival of various cell types Reducing inflammation TB-500 has poor oral bioavailability

Tirzepatide liver-fat and body-composition MRI substudy SURPASS-3, relative liver-fat reduction -29.8/-39.6/-47.1% at 5/10/15 mg vs insulin degludec -11.2%: Gastaldelli Lancet D&E 2022

Diet and nutrition: A diet rich in B12 or other essential nutrients can support faster improvements