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Downstream saturation / spare receptor full physiological response often achieved well below full occupancy because the cells downstream signaling pathway has its own ceiling

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SREBP1c expression is enhanced in patients with NAFLD, and in agreement with its lipogenic role, hepatic triglyceride levels are higher in transgenic mice overexpressing SREBP1c [44, 45], while SREBP1c knockout mice display decreased expression of lipogenic enzymes [46]

[PMID: 2920375] PubMed record related to this compound for laboratory literature review