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Classical-like EDS (type 1 cEDS) is characterized by skin hyperextensibility with velvety skin texture and absence of atrophic scarring, generalized joint hypermobility with or without recurrent dislocations (most often shoulder and ankle), and easily bruised skin or spontaneous ecchymoses (discolorations of the skin resulting from bleeding underneath)
Most published clinical data comes from AOD-9604, not the unmodified fragment
Others argue that rapid freezing at very low temperatures (below negative 20 degrees Celsius) preserves stability
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