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Common and Serious Side Effects 6.1 Frequently Reported Side Effects Dizziness and fatigue Bradycardia Hypotension Nausea and gastrointestinal upset 6.2 Serious and Rare Adverse Reactions Angioedema (particularly with ARBs) Hyperkalemia Renal dysfunction Advanced atrioventricular (AV) block 6.3 Signs Requiring Medical Attention Patients should seek immediate medical help if they experience: Sudden chest pain or palpitations Severe lightheadedness or fainting Unusual swelling, difficulty breathing, or signs of allergic reaction Drug Interactions and Product Combinations 7.1 Interactions with Antihypertensives, NSAIDs, and Diuretics Concomitant use with other blood pressure medications can increase the risk of hypotension or renal dysfunction