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Other brain regions with GLP-1 receptor expression include: Ventral tegmental area and nucleus accumbens (reward and motivation circuits) Amygdala (emotional processing and stress responses) Prefrontal cortex (executive function and decision-making) Substantia nigra (motor control, relevant to Parkinson's disease research) This widespread distribution suggests that GLP-1 influences diverse neurological functions beyond appetite regulation

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For example, a novel dual agonist of GLP-1/GIP receptors significantly increased BDNF levels in a mouse model of Parkinsons disease, induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration [53]

Waiting outside the room, they crowded around an escalator and jostled for a place in a line that extended down two floors and into a cocktail party