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The NAD+/NADH ratio determines cellular redox state, which governs everything from ATP synthesis efficiency to gene expression via sirtuins (NAD+-dependent deacetylases that regulate longevity pathways)
Our results indicated a no observed adverse effect level (NOAEL) of 2 nmol/kg/day for Ex-4 and a maximal tolerated dose (MTD) of 20 nmol/kg/day
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