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An alternative to fibrates is represented by the angiotensin II receptor blocker irbesartan, which increased PPAR signaling in the liver as well as in the kidney (Figure 2)
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In one study, switchers lost an additional 2.15 kg in just 12 weeks, along with a 0.43 percent improvement in HbA1c and 7.83 mg/dL reduction in fasting glucose
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