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Inflammation hypothesis Neuroinflammation is another typical hallmark of AD (Leng and Edison, 2021), and the relationship between microglia and astrocyte activation and the appearance of other histological AD-related alterations is unclear and heavily debated, with conflicts regarding their protective or detrimental contribution (Fiala et al., 2007

Generally, yes, but certain skin types may require adjusted dosing to prevent uneven pigmentation

Then, the significance of the association was replicated in Anstee et al., GWAS (OR = 1.58

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