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Shirasu-Hiza, D
The reduction in homocysteine levels leads to a reduction in methionine levels and methionine synthase activity: The decrease in the methionine synthase activity thus creates the well-established methyl trap, as a consequence of the one-way kinetics of 5-MTHF synthesis [Figure 2]
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Use in pregnancy, lactation and paediatric exposure has not been characterised in any published dataset, and no developmental-toxicology study has been formally reported
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