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Proper dose titration significantly reduces nausea severity

85% of participants Achieved an A1c of less than 7% Lost up to 10.6 kg (23.3 lbs) Improvements seen in 52 weeks Trial #5 Compared tirzepatide with placebo added to titrated insulin Glargine with or without metformin

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DAPI nuclear staining was used as a nuclear mask to quantify cells and allow the segmentation of cells on the basis of a Top-Hat method, according to the software guidelines