glp 1 agonist in ckd Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation image3.png

Abbreviations GCLC: Glutamate cysteine ligase catalytic subunit GCLM: Glutamate cysteine ligase modifier subunit GSH: Reduced glutathione GSSG: Oxidized glutathione ROS: Reactive oxygen species C1q: Complement component 1q C3: Complement component 3 GSDMD: Gasdermin D GSDME: Gasdermin E DAM: Disease associated microglia DAA: Disease associated astrocyte Iba1: Ionized calcium-binding adapter molecule 1 GFAP: Glial fibrillary acidic protein NeuN: Neuronal nuclei HO1: Hemeoxygenase 1 CCL: CC Chemokine ligand CXCL: C-X-C motif ligand AD: Alzheimers disease App: Amyloid precursor protein A: Amyloid beta App : NL-G-F App knockin mouse NL-G-F References Guo, C., Sun, L., Chen, X

Last year I went from stale and pale to a golden goddess

Most adults need around 65-90 mg daily, though skincare lovers often go higher (with doctor approval, of course)

Tirzepatide demonstrates significant extrahepatic benefits beyond its well-established hepatic effects, particularly in the cardiovascular and metabolic domains