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Safety and Side Effects Semaglutide, whether commercial or compounded, can cause side effects such as: Nausea Vomiting Diarrhea or constipation Fatigue Headache Serious (but rare) side effects may include: Pancreatitis Gallbladder disease Thyroid tumors (seen in animal studies) A gradual dose escalation and provider monitoring are critical to minimize risks

When the medication reaches subcutaneous tissue, it triggers a localized inflammatory response as your immune system recognizes the foreign compound

Outcome data were collected using protocol-specified measures, and each study addressed the issue of missing outcome data, implementing appropriate measures to ensure that the absence of data did not significantly impact the estimated effect sizes of the interventions

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