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The second class is inhibitors of the GLP-1 degrading enzyme, dipeptidyl pepitidase IV (Sitagliptin and related drugs) which can be given orally and increase the plasma level of GLP-1 and other peptides degraded by DPP-4
Still, results should be carefully generalized to cases of background kidney dysfunction or when using drugs with narrow therapeutic index
The regulatory timeline will follow the FDA, likely by 12 to 18 months
Phase 2: Progressive Loading (Weeks 2-4) As symptoms improve, gradually reintroduce walking and light jogging
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