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Multiple studies have demonstrated that water fasting for up to 21 days is well-tolerated [1, 2], although large studies on time frames longer than this have been limited and, to our knowledge, not incorporated the use of glucagon-like peptide-1 receptor agonists (GLP-1) for appetite suppression
Stub your toe, and pain receptors send a clear message to your brain
Drug metabolism and disposition , 36 (8), pp.1594-1605
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