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For instance, CR combined with radiotherapy, has been shown to modulate the TME in a triple-negative breast cancer model by decreasing the number of intratumoral Tregs, increasing the CD8 + cell: Treg ratio, and upregulating PD-1 expression on CD8 + T cells

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Many medically assisted weight management programs use a combination of FDA-approved and off-label options that may include GLP-1, GIP, or combination GLP-1/GIP therapies