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Research published in January 2026 found that patients who stopped taking GLP-1s returned to their baseline weight within about two years
Recent studies confirm the importance of long-term management
The most commonly referenced community protocol is 50 mcg per day for 10 consecutive days, followed by 4 weeks off (see dosing guide)
A study using fluorescently labeled lipidated analogues of exendin-4 showed that they are distributed in the hypothalamus [56]
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