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4.1 Systemic mediators of young blood action 4.1.1 Pigment epithelium-derived factor Among the serine protease inhibitor superfamily, PEDF has attracted attention as a 50-kDa secreted glycoprotein that exerts different physiological activities in various tissues, especially reducing myocardial fibrosis in HF while promoting cardiomyocyte apoptosis, thereby accelerating the progression of HF (6567)