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However, when GPX4 activity or GSH availability is diminished, lipid peroxide accumulation increases, facilitating ferroptosis initiation [21, 165]
An RCT in 72 patients with NAFLD found that NAC (600 mg twice daily) for 3 months significantly improved liver enzymes (ALT, AST) and markers of oxidative stress compared to control, though it did not significantly improve liver histology on biopsy (Khoshbaten et al., Hepat Mon, 2010) [33]
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