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This is most dramatically illustrated through differences in the intake patterns of the same drug with different routes of administration 45,46,47,48,49,50,58 known as the rate hypothesis of addiction 49,59,60
Noteworthy, these two membrane transporters are also responsible for drug uptake in the cell, further highlighting their role in developing novel anti-cancer approaches and/or improving those already existing
Although molecular mechanisms are not explicitly described, the authors highlight that these biomarkers are reliable indicators of the anti-inflammatory and antioxidant potential of GLP-1RAs, which may contribute to their cardioprotective and renoprotective actions in inflammatory conditions such as sepsis (35)
Both are medications used to aid weight loss and manage conditions like type 2 diabetes
