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One clinical trial gives a clearer picture of how often these side effects showed up at higher doses: Dysesthesia refers to unusual or unpleasant skin sensationsthings like tingling, burning, prickling, or a feeling that skin is overly sensitive to touch, sometimes described as a sunburned feeling without any visible cause

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Other GLP-1s like Ozempic and Mounjaro are sometimes prescribed off-label for weight loss, though off-label prescriptions are unlikely to be covered by insurance

MOTS-c A mitochondrial peptide with distinct energy metabolism research relevance