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While necessary, this phase transforms toxins into "reactive intermediate metabolites" that are frequently more toxic and volatile than the original substance, generating massive amounts of free radicals

We use the model to study the extent of liver damage caused by overdoses or by chronic use of therapeutic doses, and the effects of polymorphisms in glucoronidation enzymes

The compounds were incubated in the presence of rat blood serum samples and all of the resulting incubates were analyzed by HPLC in order to determine their rate of metabolic activity

NPI-001 depleted cystine from human cystinosis fibroblast cells in culture statistically significantly greater than cysteamine